Acute tolerance to overdose of Alfaxan® at 5 times the registered dose (i.e. 25 mg/kg) in cats and 10 times the registered dose (i.e. 20 mg/kg) in dogs was demonstrated where animals required only ventilation to allow recovery with no residual effects.
Muir, W., et al., Cardiorespiratory and anesthetic effects of clinical and supraclinical doses of
alfaxalone in dogs.Vet Anaesth Analg, 2008. 35(6): p. 451-462.
Muir, W.,et al., The cardiorespiratory and anesthetic effects of clinical and supraclinical doses of alfaxalone in cats.Veterinary Anaesthesia and Analgesia, 2009. 36(1): p. 42-54.
Repeated overdosing with Alfaxan® - 5 times the registered dose every 48 hours over a six day period caused no adverse effects.
Pasloske, K. and T. Whittem, JX9604.07-H004 A target animal safety study in cats after
administration of Alfaxan® -CD RTU as single, repeated injections on days 0, 2, and 5 at dosages of 5,
15 or 25 mg/kg.2004, On File at Jurox
Whittem, T. and K. Pasloske, RD9604.03-H005 Eight day target animal safety study of intravenous
Alfaxan® CD RTU in dogs administered every other day.2004, Jurox Pty Limited
Alfaxan® does not cause tissue irritation should accidental peri-vascular or subcutaneous injection occur.
Heit, M.C., et al. Safety and efficacy of Alfaxan® CD RTU Administered once to cats subcutaneously
at 10 mg/kg.in ACVIM. 2004
Alfaxan® can be safely used in puppies and kittens from 12 weeks of age
Zaki, S., K. Ticehurst, and Y. Miyaki, Clinical evaluation of Alfaxan®-CD(R) as an intravenous
anaesthetic in young cats.Aust Vet J, 2009. 87(3): p. 82-7
O’Hagan, B., et al., Clinical evaluation of alfaxalone as an anaesthetic induction agent in dogs less
than 12 weeks of age.Australian Veterinary Journal, 2012. 90(9): p. 346-50
O’Hagan, B., et al., Clinical evaluation of alfaxalone as an anaesthetic induction agent in cats less
than 12 weeks of age.Australian Veterinary Journal, 2012. 90(10): p. 395-401
Alfaxan® can safely be used prior to canine caesarean section.
Induction of anaesthesia for canine caesarean section with alfaxalone, Reproductive Biology, 2013
Metcalfe, S., et al. A multi-centre clinical trial evaluating the efficacy and safety of Alfaxan®
administered to bitches for induction of anaesthesia prior to caesarean sectionin 33 rd World Small
Animal Congress.2008. Dublin, Ireland: WSAVA/FECAVA
Alfaxan® can be safely used in greyhounds, salukis, whippets, etc.
Pasloske, K., et al., Plasma pharmacokinetics of alfaxalone in both premedicated and
unpremedicated Greyhound dogs after single, intravenous administration of Alfaxan®
at a clinical dose.Journal of Veterinary Pharmacology and Therapeutics, 2009. 32: p. 510-513.